منابع مشابه
The MET receptor tyrosine kinase in invasion and metastasis.
Various cytokines and soluble growth factors upon interaction with their membrane receptors are responsible for inducing cellular proliferation, differentiation, movement, and protection from anoikis (a planned suicide activated by normal cells in absence of attachment to neighboring cells or extracellular matrix (EMC)). Among those soluble factors a major position is exerted by hepatocyte grow...
متن کاملDysregulation of Met receptor tyrosine kinase activity in invasive tumors.
The MET protooncogene was discovered because of the ability of oncogenic Met to mediate chemically induced transformation of a human osteogenic sarcoma cell line (1). The normal product of this gene, Met, is an unusual receptor tyrosine kinase that can be distinguished from most other such proteins on the basis of its biosynthesis and its structural features. This transmembrane protein is synth...
متن کاملONCOGENIC ACTIVATION OF THE MET RECEPTOR Tyrosine Kinase PRINCIPAL INVESTIGATOR:
How signalling and biological response to the hepatocyte growth factor (HGF) receptor tyrosine kinase (RTK), Met, are coupled to Met trafficking is largely unknown. The Gab1 scaffold protein modulates Met signals involved in cell dispersal and morphogenesis. We show that Gab1 is indispensable for a form of RTK-induced actin remodelling, called dorsal ruffles, in response to HGF, epidermal and p...
متن کاملThe receptor tyrosine kinase Met and the protein tyrosine phosphatase PTPN2 in breast cancer
This is not a work of fiction. No names, characters, organisations, and events portrayed in this book are the product of the author's imagination, but are facts as known in the scientific community today. Papers I and III are open access articles and published under the terms of the Creative Commons Attribution License (CC BY), meaning that authors retain ownership of the copyright for their ar...
متن کاملReceptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1
Matrix adhesion via integrins is required for cell survival. Adhesion of epithelial cells to laminin via integrin α3β1 was previously shown to activate at least two independent survival pathways. First, integrin α3β1 is required for autophagy-induced cell survival after growth factor deprivation. Second, integrin α3β1 independently activates two receptor tyrosine kinases, EGFR and Met, in the a...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2009
ISSN: 1556-0864
DOI: 10.1097/01.jto.0000361752.86918.09